SUMMARY

Dr. Paul Saladino travels to Mallorca, Spain, to undergo Inuspheresis, a blood-filtering procedure removing toxins like pesticides, heavy metals, and microplastics, sharing the process, results, and implications for longevity.

STATEMENTS

• Inuspheresis is a therapeutic plasma filtration procedure that removes inflammatory proteins, heavy metals, microplastics, PFAS, and volatile organic compounds from the blood without needing donor plasma.
• The procedure involves drawing blood through a needle, separating plasma, filtering it through a specialized filter, and recombining it before returning it to the body, lasting 2 to 3 hours per session.
• Dr. Saladino, at 48 years old, underwent two sessions over three days in Mallorca to detoxify accumulated environmental toxins from decades of exposure, despite his recent clean animal-based diet.
• Despite optimal lifestyle choices like clean eating and avoiding plastics, unavoidable toxins such as pesticides and plastics persist in the body, necessitating advanced interventions like Inuspheresis.
• The eluate, or filtered waste from the plasma, revealed high levels of pesticides like DDE (from DDT) and lindane, along with solvents and PCBs in Dr. Saladino's sample, indicating fat-soluble accumulation over time.
• Heavy metals in the eluate were low for Dr. Saladino compared to friends who consume more fish, highlighting how dietary choices influence toxin loads.
• Post-procedure blood work showed a temporary drop in albumin and LDL cholesterol, which the body replenishes quickly, with LDL noted for its immune-protective roles against infections.
• Inuspheresis removes microplastics, one of the few therapies proven to do so, addressing environmental contaminants hard to eliminate through diet or lifestyle alone.
• The procedure costs around $3,000 per session in Europe and is expected to become more accessible and affordable in the US by 2026, potentially replacing total plasma exchange.
• While biohacking like Inuspheresis offers benefits, foundational health pillars—sleep, diet, and lifestyle—remain irreplaceable for longevity and metabolic health.

IDEAS

• Traveling to Europe for a blood-cleaning procedure combines health optimization with vacation, allowing recovery in the Mediterranean while addressing unavoidable global toxins.
• Even with a decade of ultra-clean eating, 48 years of prior exposures leave persistent fat-soluble toxins like DDE, showing how historical diet impacts current health burdens.
• Watching one's own blood circulate through a machine and return "cleaner" evokes a surreal sense of life force renewal, blending ancient detox concepts with modern technology.
• Farm-raised salmon and sushi, once dietary staples, load the body with PCBs and other contaminants, turning popular "healthy" foods into hidden toxin sources.
• LDL cholesterol isn't just a cardiovascular risk; it functions as an immune particle that protects against infections, challenging the narrative of universally lowering it.
• Reverse osmosis water and organic foods reduce but don't eliminate pesticide intake, as these chemicals bioaccumulate in fats regardless of sourcing efforts.
• Glutathione-boosting whey protein can aid post-procedure detox of mobilized heavy metals from bones and organs, but only if sourced from contaminant-free products.
• Annual Inuspheresis could track and reduce cumulative toxin loads, providing a measurable way to gauge environmental exposure over time.
• Europe's food quality, like raw milk cheese, surpasses the US, potentially lowering baseline toxin intake through regional agricultural practices.
• Comparing friends' eluates reveals how intentional low-fish diets keep heavy metals minimal, emphasizing personalized toxin profiles based on habits.

INSIGHTS

• Environmental toxins like pesticides and microplastics accumulate silently over decades in body fat, undermining even the cleanest modern diets and accelerating age-related diseases like cancer and dementia.
• Advanced filtration therapies like Inuspheresis bridge the gap between lifestyle optimization and unavoidable pollution, offering a proactive reset for longevity without replacing foundational health practices.
• Lipoproteins such as LDL serve dual roles as nutrient transporters and immune defenders, suggesting that blanket cholesterol reduction may compromise infection resistance more than it prevents heart disease.
• Historical dietary choices, including farm-raised fish consumption, create lasting toxin reservoirs that surface in later life, underscoring the value of early intervention for long-term vitality.
• Bone and organ-stored heavy metals can mobilize during plasma filtration, temporarily elevating blood levels but enabling deeper detoxification through subsequent antioxidant support.
• Personalized toxin analysis from procedures like this reveals individual exposure patterns, empowering tailored strategies that go beyond generic advice to enhance metabolic and cognitive health.

QUOTES

• "I'm curious, am I going to feel better, nothing, or worse after this blood cleaning procedure?"
• "There's just so many toxins that we're exposed to in our environment that you can't get rid of that are hard. PFAs, forever chemicals, these things take a long time to get out of our bodies."
• "I had a lifetime of poor decisions. The last 10, 15 years of my life, I've been eating super freaking clean, as clean as I possibly can. But nobody's perfect, right?"
• "What causes cancer? Why do humans get cancer? Why do humans get dementia? Well, it's insulin resistance, but it's compounds like this that we're never able to get out of our bodies."
• "I think insperesis is going to replace TPE. They're both expensive... but I think for a lot of people, this will be an expense and it'll come down over time."

HABITS

• Prioritizing an animal-based diet with fresh organs and avoiding plastic-wrapped meats to minimize microplastic and pesticide exposure.
• Drinking reverse osmosis water and sourcing beverages in glass to reduce intake of solvents and forever chemicals.
• Incorporating high-quality, low-temperature processed whey protein to boost glutathione for natural detoxification of heavy metals.
• Swimming daily in the ocean for physical recovery and mental rejuvenation post-procedure.
• Eating extra raw egg yolks post-filtration to replenish LDL cholesterol and support immune function.

FACTS

• Inuspheresis significantly reduces heavy metals between sessions, with visible dark residues in eluate indicating removal from patients with high inflammation or atherosclerosis.
• DDE, a DDT byproduct, and lindane pesticides were among the highest analytes in Dr. Saladino's eluate, persisting due to fat solubility despite organic eating.
• PCBs from farm-raised fish accumulate in body fat, contributing to higher toxin loads compared to wild or low-fish diets.
• Studies link lower LDL cholesterol to increased infectious disease mortality, positioning it as a protective immune factor.
• Microplastics, invisible in eluate, are removed by Inuspheresis, one of few therapies shown effective against these pervasive environmental pollutants.

REFERENCES

• Inuspheresis.com (procedure provider, no affiliation).
• Proxima.health (future US accessibility for Inuspheresis).
• Heart & Soil (grass-fed desiccated beef organs and clean whey protein).
• Lineage Provisions (healthy snacks from real foods).
• PubMed study on LDL-C and mortality (higher levels associated with lower infection risk).
• Clean Label Project study on contaminants in protein powders.

HOW TO APPLY

• Schedule Inuspheresis sessions at a European clinic like those in Mallorca, aiming for two treatments over three days with a rest in between to allow initial recovery.
• Prepare by getting baseline blood work for heavy metals, pesticides, and lipids to compare pre- and post-procedure results for personalized insights.
• During the 2-3 hour session, relax with provided adjustments to the machine, monitoring the blood flow through a 17-gauge needle for efficient filtration without complications.
• Post-procedure, consume nutrient-dense foods like raw egg yolks and clean whey protein to replenish lost albumin, cholesterol, and support glutathione for detoxifying mobilized toxins.
• Analyze the eluate filtrate through comprehensive lab testing to identify specific toxins like DDE or PCBs, then repeat annually to track reductions and adjust lifestyle exposures.

ONE-SENTENCE TAKEAWAY

Inuspheresis detoxifies decades of accumulated environmental toxins, enhancing longevity beyond diet alone.

RECOMMENDATIONS

• Avoid farm-raised fish and sushi to minimize PCB and heavy metal intake, opting for wild-caught or plant-free alternatives.
• Invest in annual blood filtration if toxin exposure is high, budgeting for procedures that could prevent chronic diseases.
• Boost glutathione with clean whey protein after detox therapies to clear mobilized heavy metals from tissues.
• Source water and foods in glass or non-plastic packaging to cut microplastic and solvent accumulation daily.
• Prioritize European-style raw dairy and organic meats during travel for lower baseline pesticide exposure compared to US options.

MEMO

Dr. Paul Saladino, a 48-year-old physician and advocate for animal-based nutrition, jetted off to the sun-drenched island of Mallorca, Spain, not for vacation alone but to confront a hidden enemy: the toxins embedded in his bloodstream. Jet-lagged yet exhilarated after a swim in the Mediterranean, he arrived at a sleek clinic equipped with intimidating arrays of tubes and filters. There, he underwent Inuspheresis, a cutting-edge procedure that siphons blood from the arm, separates plasma, and scrubs it of insidious contaminants—heavy metals, microplastics, pesticides, and forever chemicals—before pumping it back in. "It's like watching your life force get a deep clean," Saladino remarked, underscoring the surreal intimacy of the 2.5-hour process.

The treatment, unavailable in the U.S. until 2026, captivated Saladino for its precision: no donor plasma required, unlike traditional exchanges popularized by tech moguls. He scheduled two sessions over three days, with a restful interlude exploring raw milk cheese vendors and pristine beaches. The eluate—the murky filtrate collected—hinted at revelations; dark sediments at the bag's bottom suggested inflammatory proteins and worse. Post-session, Saladino felt a subtle fatigue, his body compensating for depleted albumin and LDL cholesterol, which he replenished with raw egg yolks. These lipoproteins, he explained, aren't mere villains in heart disease narratives but immune warriors ferrying nutrients and fending off infections.

Back in Costa Rica, lab results stunned him. Despite a decade of pristine eating—grass-fed organs, no plastic packaging—his eluate brimmed with DDE, a DDT remnant, lindane pesticides, and industrial solvents like benzene. PCBs, notorious in farm-raised salmon from his sushi-loving youth, lingered in his fat stores. Heavy metals were low, a win from his fish-avoidant diet, but friends' samples showed stark contrasts, their fish-heavy habits yielding toxic overloads. "This is 48 years of accumulated junk," Saladino reflected, linking such burdens to rising cancers and dementias beyond insulin resistance.

Microplastics, too small to see but omnipresent, emerged as Inuspheresis's quiet triumph—one of few therapies proven to evict them. Saladino, no biohacking enthusiast, views this as a vital adjunct to sleep, diet, and exercise—the unshakeable pillars of health. At $3,000 per session, it's no small investment, yet he envisions it democratizing longevity, potentially eclipsing pricier plasma swaps. Europe's superior food landscape, from unpasteurized dairy to pesticide-light produce, amplified his optimism during the trip.

A year from now, Saladino plans a sequel, testing if clean living dilutes his toxin load further. His journey illuminates a stark truth: in our polluted world, vigilance alone falters against bioaccumulants. By filtering the past from his veins, he's betting on a vital, vigorous future—one swim, one clean meal, one revolutionary rinse at a time.